So to help you several aspects of the game differ in Desolation mode from the main game.
Farming
All crops will appear in the wild, You just need to search for and collect them. You can then convert to seeds and start the process of creating your garden.Skill Tree
Skill points are now around half the cost they used to be, This is because you cannot get them for free from NPC's. The skill list differs from the main game as looting is no longer an option.Base Building
You now need to build yourself a base, Choose the location wisely, Water and food are important to survive.Horde
Every 15 minutes the Game will spawn a horde in your area, These hordes will get steadily harder and harder. Other creatures will spawn as per normal.Cauldron
Your cauldron will ask for materials that you can gather, the resulting enchantment scrolls can then be used to make your own enchantments on an anvil.I strongly suggest playing the "High Adventure" game first before tackling this DLC, A knowledge of how the basics work is required.